The institution of the place of Deep Eutectic Solvents (DESs) as a brand new class of inexperienced solvents was basically grounded on naïve comparisons with Ionic Liquids (ILs), since each are composed of charged compounds. The easiness of DESs’ preparation afforded the fast preparation and utilization of a large variety of solvents and their use in vast number of functions with minimal basic data of their thermophysical properties and part equilibria research. As time went on, the necessity to outline DESs from the thermodynamic viewpoint and to distinguish them from different courses of solvents was crucial. This angle assessment goals at dispelling some myths about DESs via the usage of experimental information and computational chemical calculations and establishing truthful comparisons with different courses of solvents, ILs, eutectic solvents (ESs) and risky natural compounds (VOCs), in order that clear and sound conclusions will be drawn. A number of necessary parameters sometimes used to characterize solvents and which were a lot used to justify DESs’ wide selection of functions, reminiscent of vapor stress, thermal stability, polarity, toxicity and water miscibility, have been accessed for these totally different solvents and comparisons have been established. Furthermore, a comparative evaluation in a particular analysis space, biopolymer dissolution and therapy, was chosen as an example the distinctive potential of ILs and DESs and the challenges that also must be addressed. Literature out there for the various polysaccharides chosen (cellulose, hemicellulose and chitin) and lignin highlighted execs and cons and the totally different stage of information gained to this point for each ILs and DESs. This half is complemented by recycling and techno-economic issues for the 2 courses of solvents, that are extra key facets to think about for the event of an efficient built-in biorefinery course of. The conclusion is clear: DESs are a brand new class of solvents, with distinct properties from different courses of solvents that are basically depending on the properties of their constituent compounds. Subsequently, when beginning compounds are properly chosen, DESs develop into a further and promising pathway within the pursuit of environmentally pleasant solvents to interchange conventional VOCs for a given software. Nonetheless, some basic research are nonetheless wanted to completely perceive these techniques and outline their best areas of software.